Preheat oven to 250°F (120°C). Prepare a large baking tray.
In a large mixing bowl, combine all cereals, pretzels, and nuts. Mix gently to distribute evenly without breaking pieces.
In a separate bowl, melt the butter fully. Add Worcestershire sauce, garlic powder, onion powder, smoked paprika, cayenne pepper, and salt. Whisk until smooth and fully combined.
Slowly drizzle the butter mixture over the cereal mix, pouring in sections for even coverage.
Gently toss the mixture using a spatula or large spoon until all pieces are evenly coated with seasoning.
Transfer the mixture onto a baking tray and spread into an even layer without pressing down. Use multiple trays if needed.
Bake for 1 hour, stirring every 15 minutes. Each time, rotate and redistribute the mix for even baking.
Remove from oven and allow the mix to cool completely on the tray. This helps it become crisp.
Once fully cooled, transfer to an airtight container and store at room temperature.